ODCs

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2 OMIM references -
2 associated genes
14 signs/symptoms

COMMON GENES: 1
COMMON SIGNS: 6

1 OMIM reference -
1 associated gene
29 signs/symptoms

Isolated cloverleaf skull syndrome

Crouzon syndrome - acanthosis nigricans

ERF	(UniProt - OMIM)		FGFR3	(UniProt - OMIM)
FGFR3	(UniProt - OMIM)

Citations in the biomedical literature:

Isolated cloverleaf skull syndrome		Crouzon syndrome - acanthosis nigricans
	Synonym(s): - Kleeblattschaedel syndrome		Synonym(s): - Crouzono-dermoskeletal syndrome

	Classification (Orphanet): - Rare bone disease - Rare developmental defect during embryogenesis - Rare genetic disease		Classification (Orphanet): - Rare bone disease - Rare developmental defect during embryogenesis - Rare eye disease - Rare genetic disease

	Classification (ICD10): - Congenital malformations, deformations and chromosomal abnormalities -		Classification (ICD10): - Congenital malformations, deformations and chromosomal abnormalities -

	Epidemiological data: Class of prevalence: unknown Average age onset: neonatal/infancy Average age of death: before age 5 Type of inheritance: sporadic		Epidemiological data: Class of prevalence: <1 / 1 000 000 Average age onset: neonatal/infancy Average age of death: - Type of inheritance: autosomal dominant

	External references: 2 OMIM references - No MeSH references		External references: 1 OMIM reference - No MeSH references


COMMON SIGNS	- Abnormal vertebral size / shape - Autosomal dominant inheritance - Beaked nose - High forehead - Mid-facial hypoplasia / short / small midface - Proptosis / exophthalmos

Isolated cloverleaf skull syndrome		Crouzon syndrome - acanthosis nigricans
	Very frequent - Depressed premaxillary region / midface - Intellectual deficit / mental / psychomotor retardation / learning disability - Low set ears / posteriorly rotated ears - Stillbirth / neonatal death Frequent - Craniostenosis / craniosynostosis / sutural synostosis - Dysostosis / chondrodysplasia / osteodysplasia / osteochondrosis / skeletal dysplasia - Restricted joint mobility / joint stiffness / ankylosis - Syndactyly of fingers / interdigital palm		Very frequent - Acanthosis nigricans - Frontal bossing / prominent forehead Frequent - Arnold-Chiari anomaly - Brachycephaly / flat occiput - Cerebellum / cerebellar vermis anomaly / agenesis / hypoplasia - Choanal atresia - Chronic uveitis / blepharitis / episcleritis / scleritis / conjonctivitis / keratitis - Conductive deafness / hearing loss - Cranial hypertension - Hydrocephaly - Hypertelorism - Hypoplastic maxillary bones / zygomatic bones / maxillary hypoplasia - Metacarpal anomalies / Archibald's sign - Ptosis - Short hand / brachydactyly - Strabismus / squint - Turricephaly / oxycephaly / acrocephaly Occasional - Facial pain / cephalalgia / migraine - High vaulted / narrow palate - Optic nerve anomaly / optic atrophy / anomaly of the papilla - Respiratory distress / dyspnea / respiratory failure / lung volume reduction - Sacro-coccyx / sacrum anomaly - Visual loss / blindness / amblyopia